WEBINAR

DUTCH In Conversation with Pendulum

Jaclyn Smeaton, ND

and Colleen Cutcliffe, PhD

| 05/07/2025 | 7:00 PM UTC

Join us for the debut of DUTCH In Conversation with Dr. Colleen Cutcliffe, PhD, CEO and co-founder of Pendulum. In this conversation, we’ll dive into the latest breakthroughs in microbiome science and explore how Pendulum is developing targeted probiotics to support metabolic health, hormone balance, and overall wellness.

Watch the replay to learn more about:

  • The evolving science behind keystone strains like Akkermansia muciniphila, its role in gut barrier integrity, metabolic function, and even longevity
  • The critical connections between the gut microbiome and women’s hormonal health, including estrogen metabolism and menopause-related shifts
  • How DUTCH Test insights can complement microbiome therapies to create a holistic approach to health optimization
  • A sneak peek at what’s next in microbiome science, from engineered probiotics to new clinical research



Key Moments

00:00 Introduction to Pendulum Therapeutics and Microbiome Science
02:59 The Journey of Research and Product Development
06:04 Understanding Akkermansia: The Keystone Strain
08:56 Gut Health and Its Impact on Overall Well-being
11:53 Food Sensitivities and the Role of Gut Integrity
14:51 The Connection Between Gut Microbiome and Immune Function
17:55 Mental Health and the Gut-Brain Axis
20:55 Hormonal Changes and Their Effects on the Microbiome
26:53 The Role of Microbiome in Estrogen Regulation
28:50 Understanding Dysbiosis and Its Impact on Hormones
30:54 The Interplay Between Hormones and Gut Health
32:36 Pregnancy and the Gut Microbiome
34:11 The Importance of Akkermansia in Gut Health
37:34 Metabolic Health and GLP-1 Peptides
40:33 The Mechanism of GLP-1 and Its Implications
42:33 Alternatives to GLP-1 Medications
46:19 The Future of Probiotics and Postbiotics



Please Note: The contents of this video are for educational and informational purposes only. The information is not to be interpreted as, or mistaken for, clinical advice. Please consult a medical professional or healthcare provider for medical advice, diagnoses, or treatment.

Disclaimer: Special offer of 50% OFF first five kits is invalid 60 days after new provider registration.



TAGS

Women's Health

Microbiome

Menopause

Metabolic Health

Estrogen Metabolism