The Science of Cognition: Assessing Brain Health Through Organic Acid Metabolomics

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In this webinar, we will discuss:

  • The intersection of metabolomics, hormone dynamics, and genetics in understanding cognitive health
  • How organic acids interact with crucial hormones like estrogen and cortisol
  • The genetic predispositions that affect metabolic pathways in the brain

As we delve into how the DUTCH Test can be used to integrate metabolite and hormonal analysis with genetic data, attendees will gain cutting-edge knowledge on assessing and managing cognitive health through a comprehensive biochemical and genetic approach. This session is designed to empower clinicians with the latest tools and research to better understand and treat cognitive disorders in their practices.


Key Moments 

  • 1:45 Introduction to Dr. O’Brien
  • 2:45 Outline and objectives of webinar
  • 4:15 Exploring Organic Acid Metabolomics
  • 5:38 The Science of Metabolomics
  • 6:30 Organic Acids in Metabolomics and Urine Testing
  • 7:36 Impact of Organic Acids on the Brain and Explaining HVA, VMA, Kynurenate, and Quinolate
  • 10:15 Practical Applications of Organic Acid Testing
  • 12:28 Key Organic Acids in Neurochemistry
  • 13:40 OATs on the DUTCH Report
  • 15:56 Hormone Metabolites on the DUTCH Report
  • 16:57 Cortisol Awakening Response 
  • 18:23 Low CAR on the DUTCH Report
  • 19:16 High CAR on the DUTCH Report
  • 20:25 Homovanillic Acid (HVA)
  • 23:26 Dysregulation of Dopamine Production
  • 24:40 Impact of Genetics on Cognitive and Psychological Health
  • 26:56 Things that Elevate and Reduce HVA
  • 27:52 Biological Markers for Stress Impact (HVA)
  • 34:06 Dopamine Boosting Foods
  • 35:09 Vanillylmandelic Acid (VMA)
  • 36:43 Norepi/Epigenetics
  • 37:06 Effects of Noradrenaline and Adrenaline on Stress
  • 42:00 Foods that Increase Norepinephrine/Epinephrine
  • 43:04 The Relationship Between HVA and VMA
  • 48:43 Kynurenate and Quinolate
  • 50:33 The Neuroprotective Effects of Kynurenate
  • 52:05 Food Sources of Kynurenic Acid
  • 53:22 Biological Markers for Stress Impact (Kynurenate)
  • 56:20 Quinolinate
  • 58:04 Biological Markers for Stress Impact (Quinolinate)
  • 1:00:16 Foods to Reduce the Negative Effects of Quinolinic Acid
  • 1:01:20 Methylmalonate (MMA)
  • 1:02:45 Biological Markers for Stress Impact (Methylmalonate)
  • 1:03:49 Xanthurenate
  • 1:03:59 Biological Markers for Stress Impact (Xanthurenate)
  • 1:06:44 Pyroglutamate
  • 1:07:33 Biological Markers for Stress Impact (Pyroglutamate)
  • 1:08:32 Indican
  • 1:09:50 8-OH-dG
  • 1:10:00 Biological Markers for Stress Impact (8-OH-dG)
  • 1:13:36 Making the Connection Between OATs, Hormones, and Brain Health
  • 1:17:45 Estrogen, Cortisol, and Neurotransmitter Metabolism
  • 1:18:44 Hormone Metabolites on the DUTCH Report
  • 1:19:56 Personalized Medicine in Cognitive Health
  • 1:20:54 Key Takeaways from the webinar
  • 1:21:56 Closing and Thank You

Please Note: The contents of this video are for educational and informational purposes only. The information is not to be interpreted as, or mistaken for, clinical advice. Please consult a medical professional or healthcare provider for medical advice, diagnoses, or treatment.

Disclaimer: Special offer of 50% OFF first five kits is invalid 60 days after new provider registration.