Episode 141

Published February 17, 2026

In this conversation recorded live at A4M LongevityFest 2025, Kiran Krishnan and Dr. Jaclyn Smeaton discuss the critical role of the skin microbiome in overall health, emphasizing its impact on skin barrier function and the consequences of dysbiosis.

Dr. Smeaton and Kiran also discuss:

• The connection between gut health and skin conditions like acne and atopic dermatitis
• Personal care products and lifestyle choices that can affect skin health
• Foundational strategies for maintaining a healthy skin microbiome
• Microbial migration from the skin and how it can affect other body systems
• How dysbiosis disrupts pH, collagen, and immune tolerance

Key Moments

0:46 Introduction to the Skin Microbiome

2:37 The Importance of Skin Microbiome in Health

6:53 Dysbiosis and Its Impact on Skin Health

10:35 Microbiome's Role in Skin Barrier Function

12:43 Effects of Hand Sanitizers on Skin Microbiome

15:41 Microbial Migration and Systemic Effects

18:32 The Connection Between Gut and Skin Health

22:43 Acne: Microbial Patterns and Treatments

24:16 Become A DUTCH Provider

25:01 Acne: Microbial Patterns and Treatments (Cont'd)

27:41 Inflammatory Skin Conditions and Microbiome Solutions

39:57 Foundational Strategies for Skin Health

About our speaker

Kiran Krishnan is a Research Microbiologist and has been involved in the dietary supplement and nutrition market for the past 17 years. He comes from a strict research background having spent several years with hands-on R&D in the fields of molecular medicine and microbiology at the University of Iowa. He left University research to take a position as the U.S. Business Development and Product Development lead for Amano Enzyme, USA. Amano is one of the world’s largest suppliers of therapeutic enzymes used in the dietary supplement and pharmaceutical industries in North America. Kiran also established a Clinical Research Organization where he designed and conducted dozens of human clinical trials in human nutrition.

Kiran is also a co-founder and partner in Nu Science Trading, LLC.; a nutritional technology development, research and marketing company in the U.S. Dietary Supplement and Medical Food markets. Most recently, Kiran is acting as the Chief Scientific Officer at Physician’s Exclusive, LLC. and Microbiome Labs. He has developed over 50 private label nutritional products for small to large brands in the global market. He is a frequent lecturer on the Human Microbiome at Medical and Nutrition Conferences. He conducts the popular monthly Microbiome Series Webinars through the Rebel Health Tribe Group practitioner training program, is an expert guest on National Radio and Satellite radio and has been a guest speaker on several Health Summits as a microbiome expert. He is currently involved in 9 novel human clinical trials on probiotics and the human microbiome.

Kiran is also on the Scientific Advisory Board for 5 other companies in the industry. Kiran offers his extensive knowledge and practical application of the latest science on the human microbiome as it relates to health and wellness.

Show Notes

Learn more about Kiran Krishnan, PhD on Instagram @kiranbiome!

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