Episode 135

Published January 6, 2026

In this conversation, Dr. Jaclyn Smeaton, Mark Newman, MS, and Dr. Kara Fitzgerald discuss her groundbreaking work on biological age reversal through dietary patterns and lifestyle interventions.  

This episode also explores: 

• The role of epigenetics, polyphenols, and urolithin A in longevity 
• How dietary patterns can influence biological age 
• The impact of stress on hormonal health and methylation 
• Nutrition and lifestyle as important parts of functional medicine 
• How lifestyle changes can reverse biological age 

Key Moments

0:09 Introduction to The DUTCH Podcast and Guests

2:35 Exploring Epigenetics and Clinical Trials

6:27 Dietary Patterns and Biological Age Reversal

10:38 Understanding Polyphenols and Their Impact

16:11 The Role of Urolithin A in Health

21:32 Become a DUTCH Provider

22:18 Stress, HPA Axis, and Hormonal Health

27:30 Methylation and Estrogen Metabolism

45:54 Key Takeaways from Younger You

About our speaker

Dr. Kara Fitzgerald, ND, IFMCP, is engaged in clinical research on DNA methylation using diet and lifestyle interventions developed in her virtual and in-person functional medicine clinic. She published a consumer book, Younger You, and a companion program based on her ground-breaking eight-week study that resulted in a three-year reversal of biological aging.  

Dr. Fitzgerald is a faculty member at the Institute for Functional Medicine (IFM) and is an IFM certified practitioner. She regularly lectures internationally and is the host of the podcast New Frontiers in Functional Medicine. 

Show Notes

Learn more about Dr. Kara Fitzgerald and her book, Younger You. Follow her on Instagram @drkarafitzgerald! 

Become a DUTCH Provider to learn how the DUTCH Test can profoundly change the lives of your patients. 

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