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Ovarian Aging, Progesterone Decline & Hidden Drivers of Early Perimenopause
Cynthia Thurlow, NP
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Episode 139
Published February 3, 2026
In this episode recorded live at A4M LongevityFest 2025, Dr. Jaclyn Smeaton and Cynthia Thurlow discuss critical aspects of women's health, focusing on ovarian senescence, perimenopause, and the impact of lifestyle choices on hormonal health.
This episode also covers:
- Understanding ovarian senescence and how it impacts women’s biological clock
- Menstrual cycles as vital signs of health, not just inconveniences
- The necessity of addressing symptoms that women often accept as normal
- How strength training, intermittent fasting, and digestive rest can be beneficial in midlife
- Using personalized lab testing to guide treatment strategies
Key Moments
0:51 Introduction to Women's Health and Hormonal Changes
2:10 Understanding Ovarian Senescence and Aging
4:32 The Impact of Lifestyle on Ovarian Health
7:16 Perimenopause: Symptoms and Early Indicators
11:49 Normal vs. Optimal: Redefining Women's Health
16:26 Become A DUTCH Provider
17:12 The Role of Lifestyle Changes in Midlife Health
20:16 Strength Training: A Key to Longevity
23:23 Intermittent Fasting: Strategies for Women
26:17 Digestive Rest: Importance and Benefits
31:47 Lab Testing and Personalized Health Strategies
About our speaker
Cynthia Thurlow is a globally recognized expert in nutrition & women's health, highly sought after speaker, and the CEO and founder of Everyday Wellness Project. She’s been a nurse practitioner for 20+ years, is a 2x TEDx speaker: her 2nd talk on intermittent fasting has been viewed over 7 million times. She has been featured on ABC, FOX5, KTLA, CW and in Medium and Entrepreneur. Cynthia was recently listed in Yahoo Finance as one of the “21 founders changing the way we do business.” She’s also the host of Everyday Wellness Podcast, which was listed as “20 podcasts that will help you grow in 2020” by Entrepreneur magazine, and in Business Insider “21 podcasts to expand your mind in 2021.”
Show Notes
Learn more about Cynthia Thurlow and follow her on Instagram @cynthia_thurlow_!
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TAGS
Women's Health
Perimenopausal Women
Perimenopause
Menstrual Cycle
Diet and Fasting
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