Episode 158

Published June 23, 2026

In this episode, Dr. Bindiya Gandhi joins host Dr. Jaclyn Smeaton to explore GLP-1 receptor agonists through a whole-person, root-cause lens with a particular focus on women’s health.

Their discussion also covers:

• How GLP-1s work, who benefits most, and how to cease therapy successfully
• The role of leptin resistance in weight struggles
• The risk of muscle loss and bone health during GLP-1 therapy
• Using GLP-1s as part of a comprehensive protocol, including optimizing gut health, strength training, and managing cortisol and sex hormones
• Considerations for menopausal women using hormone therapy in addition to GLP-1s

Key Moments

0:54 Episode Introduction

2:48 Journey to Functional Medicine

5:36 Understanding Metabolic Dysfunction in Women

8:42 The Role of Leptin and Insulin Resistance

11:49 GLP-1s: Mechanisms and Patient Considerations

14:56 Women’s Hormonal Status and GLP-1 Response

17:45 Gut Health and Weight Loss Dynamics

20:51 DUTCH Courses: Mastering Functional Hormone Testing

21:36 Cortisol, Stress and Weight Management

28:40 Emerging Research on GLP-1s and Health Benefits

33:54 The Role of GLP-1 in Weight Management

35:38 Exploring New GLP-1 Options

41:45 Potential Beyond Weight Loss: Autoimmune Conditions

43:13 Life After GLP-1: Managing Expectations

49:29 Staying Informed: The Provider's Role

52:38 GLP-1 Research and Additional Resources

About our speaker

Dr. Bindiya Gandhi is a double board-certified Family and Integrative Medicine physician and Founder and Medical Director of Revive Atlanta MD. With over a decade of clinical experience, she specializes in obesity, insulin resistance, and metabolic dysfunction, with a particular focus on the hormonal drivers of weight regulation including leptin resistance and GLP-1 signaling. An early clinical adopter of GLP-1 therapies, Dr. Gandhi has treated thousands of patients and developed a systems-based approach that combines precision diagnostics, gut microbiome optimization, and targeted nutrition to address the root causes of weight loss resistance. Her work centers on reframing obesity as a neurohormonal signaling disorder, and her mission is to replace shame with science in the conversation around sustainable weight loss. 

Show Notes

Learn more about Dr. Bindiya Gandhi and follow her on Instagram @drbindiyamd!

Check out our DUTCH Article on GLP-1s and perimenopause.

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