Episode 121

Published September 9, 2025

In this episode, Dr. Chris Renna discusses his transition from traditional family medicine to longevity medicine, emphasizing the importance of preventive health and hormone management in aging.

Dr. Renna and Dr. Smeaton also explore:

• The role of hormones in aging and as essential tools for managing our bodies
• The evolution of hormone therapy, particularly considering the Women's Health Initiative findings
• Cultural shifts in public awareness regarding longevity
• The importance of patient-centered approaches in hormone therapy
• Metabolic flexibility and mitochondrial health, emphasizing the significance of energy production and efficiency in maintaining health as we age

Key Moments

0:00 Introduction to Longevity Medicine

3:30 The Shift from Traditional to Preventive Medicine

6:26 The Role of Hormones in Longevity

10:53 Understanding Aging and Hormonal Influence

15:46 Cultural Shifts in Longevity Awareness

20:33 The Evolution of Hormone Replacement Therapy

27:31 Bioidentical vs. Synthetic Hormones

32:30 The Importance of Progesterone

36:44 Patient-Centered Approaches in Hormone Therapy

41:21 Metabolic Flexibility and Mitochondrial Health

About our speakers

Dr. Chris Renna graduated cum laude from the University of North Texas Health Science Center and completed his residency in family medicine after earning his degree from the University of Texas. Realizing traditional medical training focused on diagnosing disease rather than creating health, he founded LifeSpan Medicine in 1992 to deliver personalized, preventive care through concierge support and comprehensive evaluations. His practice centers on optimizing health with a patient-first philosophy: everything is about you and your health.  

Show Notes

Learn more about Dr. Renna’s practice, LifeSpan Medicine, and follow them on Instagram @lifespanmedicine!

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