Episode 148

Published April 7, 2026

In this episode, Dr. Jaclyn Smeaton and DUTCH Founder Mark Newman discuss a case study published in Integrative Medicine: A Clinician’s Journal in which Mark himself was the patient. The case covers the step-by-step hormonal and metabolic effects of using HCG to boost endogenous testosterone, revealing how increasing testosterone can cascade into elevated estrogen, impaired estrogen clearance, and strained methylation capacity.

Their conversation also highlights:

• The benefits of combining serum testing and DUTCH testing to monitor dosing as well as metabolism, clearance, and methylation
• How methylation is affected by raising testosterone
• The value of tracking step-by-step supplementation plans with repeated testing
• The importance of baseline testing before beginning testosterone therapy
• An upcoming research publication that compares hormone testing methods for testosterone monitoring

Key Moments

0:35 Episode Introduction

1:52 Introduction to the Case Study

3:16 Testosterone Monitoring and DUTCH Testing

4:54 Understanding Testosterone Levels in Men

8:17 Interventions for Increasing Testosterone

12:12 The Impact of Estrogen on Testosterone Therapy

13:22 Strategies for Managing Estrogen Levels

14:45 Improving Estrogen Clearance and Methylation

19:22 The Role of Trimethylglycine in Methylation

23:37 Become A DUTCH Provider

26:19 Case Study Conclusion and Clinical Implications

28:18 Understanding Stress Responses and Biochemistry

29:43 Testing and Monitoring Hormone Therapy

35:59 Testosterone Therapy in Women

39:25 The Role of Serum vs. Saliva Testing

44:14 Evaluating Evidence in Hormone Therapy

47:35 The Importance of Scientific Integrity

About our speaker

Mark Newman, MS, is a recognized expert and international speaker in the field of hormone testing. Mark spent nearly 25 years developing and directing 24-hour urine, organic acid, and salivary hormone testing labs. His unique experience led him to pursue a revolutionary way to test hormones.  

Mark began his own lab, Precision Analytical Inc., to create the most comprehensive functional hormone test available, DUTCH®—Dried Urine Test for Comprehensive Hormones. Mark is committed to making it easier for patients and their healthcare providers to answer complex clinical questions through extensive education on validated hormone research. Every day, he and his team of experts work toward their mission to profoundly change one life, and then a million more through industry-leading functional hormone testing and education. 

Show Notes

Read the DUTCH article and access the full IMCJ case report.

Become a DUTCH Provider to see how the DUTCH Test can profoundly change the lives of your patients.

Disclaimer: Special offer of 50% OFF first five kits is invalid 60 days after new provider registration.