Episode 98

Published March 25, 2025

In this conversation, Dr. Mohit Khera discusses the critical role of testosterone in men's health, its implications for various comorbid conditions, and the importance of lifestyle modifications. He emphasizes the need for regular testosterone level checks, especially for men over 40, and explores the interplay between testosterone and mental health. 

This episode also covers:

• The definition of low testosterone 
• Underlying causes of low testosterone, including obesity and stress 
• How to optimize testosterone levels with a holistic approach that includes diet, exercise, sleep, and stress management
• The critical relationship between health span, sexual health, and preventative care 
• The importance of early screening for conditions like erectile dysfunction, which can signal underlying cardiovascular issues 
• The interconnectedness of hormonal health, particularly the balance of testosterone, estrogen, and progesterone

Key Moments

00:00 Introduction to Dr. Mohit Khera
00:53 The Importance of Testosterone in Men's Health
03:12 Testosterone and Comorbid Conditions
06:23 The Interplay of Testosterone and Mental Health
08:09 Defining Low Testosterone
10:32 Understanding Testosterone Receptor Sensitivity
12:18 Optimizing Testosterone Levels
14:12 Concerns About Testosterone Over-Prescription
16:08 Underlying Causes of Low Testosterone
20:02 Symptoms of Low Testosterone
22:27 Lifestyle Modifications for Testosterone Optimization
23:24 The Importance of Health Span and Sexual Health
24:42 Early Screening and Preventative Care
25:53 Erectile Dysfunction as a Warning Sign
29:44 Testosterone in Women: A Neglected Topic
32:02 The Stigma Around Female Testosterone Therapy
35:12 Potential Benefits of Testosterone for Women
39:49 The Triangle of Hormonal Health: T, E, and P

About our speaker

Dr. Khera earned his undergraduate degree from Vanderbilt University, his MBA and Masters in Public Health from Boston University, and his Medical Degree the University of Texas Medical School at San Antonio. He completed his Urology residency and Male Reproductive Medicine fellowship at Baylor College of Medicine. He holds the F. Brantley Scott Chair in Urology at Baylor. Dr. Khera specializes in sexual dysfunction, Men’s Health, and hormone replacement therapy. He is also Director of the Laboratory for Andrology Research, Medical Director of the Baylor Executive Health Program, and President of the Sexual Medicine Society of North America. 

Show Notes

Check out the study referenced by Dr. Khera on the effect of testosterone supplementation on depression symptoms, the study on erectile dysfunction and cardiovascular disease, and explore the Sexual Men’s Society of North America website.

Learn more about Dr. Khera and follow him on Instagram @drmohitkhera!

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