Hormones & Bone Metabolism in Men: Testosterone, Estradiol & Osteoporosis Risk
Doug Lucas, DO
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Episode 178
Published November 10, 2026
In this episode, Dr. Doug Lucas joins host Dr. Jaclyn Smeaton to discuss osteoporosis in men, how falling testosterone affects bone, and the risk of bone loss from GLP-1 use.
This episode also highlights:
- The higher mortality rate in men after a fragility fracture due to fractures typically occurring later when bone is more fragile
- Common risk factors, such as hormone imbalance, high stress, and gut disorders
- The relationship between declining testosterone and declining estradiol, which is crucial for bone health
- Dr. Doug’s recommendations for approaching bone scans and analyzing bone turnover markers
- Tips for maintaining bone while using GLP-1s, including resistance training, adequate protein, and a baseline DEXA scan before starting
Key Moments
0:40 Episode Introduction
3:38 Dr. Lucas' Background and Shift into Education
6:37 Is Osteoporosis Reversible?
8:10 Bone Health: A Blindspot in Men's Health
12:23 More Than Muscle: GLP-1s and the Loss of Bone Density
17:43 Testosterone and Its Effect on Bone Health
24:40 Estradiol and Its Effect on Bone Health
29:14 DUTCH Fest 2027: Early Bird Pricing
29:47 What Hormone Testing Can Offer Your Patients
38:44 Far from Perfect: When and How to Use the DEXA Scan
44:18 Risk Factors in Men and Next Steps
52:57 Top Level Recommendations for Bone Health
About our speaker
Dr. Doug Lucas is a double board-certified orthopedic surgeon and osteoporosis specialist. He "retired" from orthopedics to further his mission to educate the world that osteoporosis is not only preventable but often reversible. His personal health story led him to the world of functional medicine and BioHacking which he brings to the bone health space. To help achieve his professional mission Dr Doug wrote two Amazon best-selling books, "The Osteoporosis Breakthrough" and "Top 10 Reasons Why Your Hormones are Failing You!" He also started the hit YouTube channel The Dr Doug Show: Bones, Hormones and HealthSpan. He serves as the founder and lead physician for his nationwide clinical telehealth practices Optimal Human Health MD and Pema BioIdentical as well as the team leader for his international osteoporosis community The OsteoCollective. Dr Doug now travels the globe spreading the message that bone and muscle health are THE KEY to longevity and HealthSpan!
Show Notes
Learn more about Dr. Doug Lucas, The Osteo Collective, and follow him on Instagram @dr_douglucas!
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TAGS
Men's Health
Bone Mineral Density
Estrogen
Testosterone
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