Episode 132

Published December 2, 2025

In this conversation, Dr. Amy Killen discusses her exploration of hormone optimization therapy and the evolving landscape of women's health. 

Dr. Killen and Dr. Smeaton also discuss:

• The multifaceted impact of progesterone and estrogen on women's health, particularly in relation to brain and bone health 
• Multi-omic studies and how they can aid in understanding longevity
• Ongoing research in ovarian aging and the role of ovarian aging in women's health
• The potential of stem cell therapy in promoting longevity
• The future of women's health and the need for greater access to hormone therapy 

Key Moments

0:18 Podcast Intro

3:19 The Journey to Longevity Medicine

6:19 Balancing Motherhood and Medicine

9:21 Transitioning from ER to Regenerative Medicine

12:08 Evaluating New Therapies in Medicine

15:11 Understanding Hormone Optimization Therapy

18:08 The Future of Hormone Therapy

21:28 Cultural Shifts in Hormone Awareness

24:20 The Role of Progesterone in Women's Health

26:54 Updates to the DUTCH Report

28:00 The Role of Progesterone in Women's Health (cont'd)

33:11 The Impact of Estrogen on Brain and Bone Health

35:29 Understanding Multi-Omic Studies in Longevity Medicine

39:24 The Role of Ovaries in Women's Longevity

41:46 Exploring Stem Cell Therapy for Longevity

44:22 Integrating Aesthetics and Longevity Medicine

47:15 The Importance of Hormone Testing

57:40 Future Directions in Women's Health

About our speaker

Dr. Amy Killen, MD, is a leading expert in longevity and regenerative medicine who helps people move beyond simply surviving to truly thriving. After beginning her career as a board-certified emergency physician, she shifted her focus to human optimization, blending hormones, peptides, and regenerative therapies to support vitality at every age. As the co-founder and Chief Medical Officer of Humanaut Health and the founder of the Human Optimization Project (HOP), Dr. Killen is passionate about empowering women to reclaim their health and confidence. She is widely recognized for her engaging, science-based approach to wellness and aging. 

Show Notes

Learn more about Dr. Amy Killen and follow her on Instagram @dr.amybkillen!

Check out the brain and immune system aging study from Nature Medicine and the transdermal estradiol study from Menopause mentioned in this episode.

Become a DUTCH Provider to learn more about how the DUTCH Test can profoundly change the lives of your patients.

Disclaimer: Special offer of 50% OFF first five kits is invalid 60 days after new provider registration.