Episode 123

Published September 23, 2025

In this episode, Lexi Yoo discusses the importance of personalized medicine, the role of hormone therapy in managing symptoms, and the significance of lab testing in understanding hormonal health.

This conversation also covers:

• The complexities of estrogen metabolism
• How testosterone therapy can impact women's health
• Hormone therapy particularly in relation to breast cancer risk
• Outdated beliefs surrounding hormone therapy
• The importance of individualized treatment plans for women, especially those with a history of breast cancer
• Potential benefits of both oral and transdermal hormone therapies

Key Moments

0:00 Introduction to Hormones and Wellness

2:00 Breast Cancer and Hormone Therapy

7:07 Navigating Menopause: Patient Concerns

12:10 Understanding Hormonal Testing

18:09 Estrogen Metabolism and Breast Cancer Risk

29:08 Understanding Hormonal Influences

30:01 Breast Cancer and Hormone Therapy Concerns

32:28 The Role of Testosterone in Women's Health

35:45 Navigating Hormone Replacement Therapy

37:44 Vaginal Hormones and Quality of Life

40:20 First Pass Metabolism and Hormone Safety

44:14 Synthetic vs Natural Hormones

45:35 Personalized Approaches to Hormone Therapy

49:07 Neurotherapy and Hormonal Balance

52:24 Rewriting the Narrative on Hormone Therapy

About our speaker

Lexi Yoo is the CEO and founder of Yoo Direct Health. A double-board-certified nurse practitioner in family and pediatric care, she also holds functional medicine certification and advanced training in aesthetics and peptide therapy. With extensive experience in guiding women through perimenopause and menopause, Lexi specializes in personalized hormone optimization strategies that improve quality of life and long-term health. Lexi also hosts The Better Yoo Project podcast, where she shares insights on health, hormones, longevity, and aesthetics. 

Show Notes

Learn more about Lexi Yoo and follow her on Instagram @lexiyoonp!

Check out Lexi Yoo’s podcast, The Better Yoo Project, and the Yoo Direct Health Training Academy.

Read more about the testosterone implant study as well as the 2025 update to the study.

Become a DUTCH Provider to learn how the DUTCH Test can profoundly change the lives of your patients.

Disclaimer: Special offer of 50% OFF first five kits is invalid 60 days after new provider registration.