DUTCH Cycle Mapping™ PLUS

Cycle Mapping™ PLUS combines the full picture of a woman’s cycle and adds salivary measurements of the Cortisol Awakening Response (CAR) to bring another important piece of the HPA axis
into focus and answer important questions for patients with month-long symptoms, infertility, and PCOS.

What is Cycle Mapping™ PLUS?

The DUTCH Cycle Mapping™ PLUS not only maps estrogen and progesterone through the monthly menstrual cycle but also adds the comprehensiveness of all the hormone metabolites along with the cortisol awakening
response (CAR).

Hormonal balance is key. Fluctuating levels of estradiol and progesterone play a major role in a woman’s overall health. This panel is designed for cycling women who struggle with ongoing symptoms such as monthly migraines, fertility issues, or PCOS. The addition of the cortisol awakening response (CAR), a transient, immediate rise in cortisol upon awakening (distinct from the diurnal rhythm), provides a fuller assessment of hormone fluctuations, baseline stress response, and reflects a patient’s ability to cope with anticipated challenges. CAR also shows a patient’s perception of control around chronic stress, providing insight into HPA resiliency.

WHEN IS CYCLE MAPPING™ PLUS RECOMMENDED?

Women struggling with infertility
Women with cycling hormones and no menses
Partial hysterectomy (ovaries intact but no uterus)
Ablations
Mirena IUD (no actual menstrual bleeding due to IUD but still has hormonal symptoms)
Women with irregular cycles
PCOS
If the luteal phase shifts from month-to-month
Not sure when to test due to long or short cycles
Women whose hormonal symptoms tend to fluctuate throughout the cycle
PMS, mid-cycle spotting, migraines, etc.

WHEN IS CYCLE MAPPING™ PLUS NOT NEEDED? (DUTCH COMPLETE™ IS SUFFICIENT)

Postmenopausal women
Women on birth control
Women with cycles that follow the expected pattern

Charming female doctor giving advice to a female patient.
Cycle Mapping™ PLUS

Most Convenient Method for Month-Long Analysis

EASY SAMPLE COLLECTIONS MAKE FOR BETTER TESTING

DUTCH Cycle Mapping™ PLUS uses more sample collections for mapping (first-morning urine collections) and performs testing on targeted samples based on the actual length of the cycle. In addition, one full day of four (4) urine and five (5) saliva samples are collected, providing the comprehensive hormone metabolite and cortisol awakening responce (CAR) results.

WHAT CAN INCLUDING THE DUTCH PLUS®
AND CAR TELL YOU?

Even though a patient may have “normal” free cortisol levels throughout the day, that does not always mean everything is functioning properly. The graph below shows two good examples. A blunted or exaggerated CAR can appear even when single samples return “normal” results. The HPA axis might not be appropriately responding when faced with a stressor, even when cortisol levels are fluctuating nicely throughout the day.

Daily Free Cortisol graph

DO DRIED SAMPLES COMPROMISE THE ANALYSIS?

Dried samples are accurate for hormone testing, and values correlate to liquid samples (see graph, below).

Linearity_Liquid_vs_Strip_Feb12_2013 1