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Comparing Urinary Estrogen Profiles of Women
on Transdermal Estradiol Patches, Gels, or Creams
Mark Newman, MS1; Doreen Saltiel, MD, JD1,2; Bryan P. Mayfield, PharmD1,3; Frank Stanczyk, PhD4
1Precision Analytical, McMinnville, OR; 2Peak Health and Wellness, Asheville, NC; 3Texas Tech University Health Sciences Center Jerry H. Hodge School of Pharmacy, Lubbock, TX; 4University of California Keck School of Medicine, Los Angeles, CA
Research
Transdermal (TD) estradiol (E2) patches and gels are the two most commonly used TD E2 formulations; however, some providers choose to treat patients with compounded E2 creams. We set out to understand the comparative effects of these 3 different TD delivery systems given their complex and differing pharmacokinetics, while also considering the fact that there is essentially no published data supporting the efficacy of compounded E2 creams. E2 levels are most often measured in serum, but these values may not be the most accurate, especially since creams and gels show significant variation in E2 levels throughout the day, and serum only represents one moment in time. Our study sought to determine if urinary E2 levels could provide an accurate representation of serum E2 concentrations over a 24-hour period.
Results
Our results demonstrated the changes in urinary E2 profiles in response to increasing doses of E2 patches, gels, and creams. These results suggest that our validated dried urine assay (the DUTCH Test®) could, in fact, provide an attractive alternative or complement to serum when monitoring TD E2 therapy. Our relentless pursuit for the best hormone monitoring tools available will drive us to perform even more studies in the future to improved the precision and personalization of MHT.
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References
1. Newman M, Pratt SM, Curran DA, Stanczyk FZ. Evaluating urinary estrogen and progesterone metabolites using dried filter paper samples and gas chromatography with tandem mass spectrometry (GC–MS/MS). BMC Chemistry. 2019;13(1):1-12. doi:10.1186/s13065-019-0539-1
More DUTCH Research
With a validated test, providers gain clinical confidence in their MHT treatments.
Precision Analytical, Inc. published its first peer-reviewed journal in BMC Chemistry in 2019. Since then, our rigorous pursuit for the truth has led us to author multiple peer-reviewed research studies exploring the effectiveness and accuracy of dried urine testing to measure comprehensive hormones. We invite you to explore our other research, and discover how the DUTCH Test® can be a valuable tool to solve complex patient problems.
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