Click Here to download a PDF version of this poster
Monitoring Estradiol Patch Therapy
with a Validated Dried Urine Assay
Mark Newman, MS1; Doreen Saltiel, MD, JD1,2; Bryan P. Mayfield, PharmD1,3; Frank Stanczyk, PhD4
1Precision Analytical, McMinnville, OR; 2Peak Health and Wellness, Asheville, NC; 3Texas Tech University Health Sciences Center Jerry H. Hodge School of Pharmacy, Lubbock, TX; 4University of California Keck School of Medicine, Los Angeles, CA
Research
Estradiol (E2) patches are one of the most commonly used menopausal hormone therapy (MHT) formulations, and, as a result, are also one of the most studied. Many of these studies use serum testing; however, a great deal of intra and inter-subject variability exists in serum levels. This study set out to investigate whether urine could provide a representation of serum E2 levels over a 24-hour period because, in contrast to serum, urine sampling is non-invasive and easier to collect.
Results
This study demonstrated that a validated dried urine assay (the DUTCH Test®)is a viable method for monitoring changes in women’s urinary E2 profiles in response to MHT with differing doses of TD E2 patches. Because the urine collection process is simpler and urinary E2 represents serum E2 levels over a 24-hour period, dried urine testing can be an attractive alternative or complement to serum for exploring not only the changes in the urinary estrogen profile, but also the efficacy and effectiveness of TD E2 patches.
Download the Full Research Poster
References
1. Newman M, Pratt SM, Curran DA, Stanczyk FZ. Evaluating urinary estrogen and progesterone metabolites using dried filter paper samples and gas chromatography with tandem mass spectrometry (GC–MS/MS). BMC Chemistry. 2019;13(1):1-12. doi:10.1186/s13065-019-0539-1
More DUTCH Research
With a validated test, providers gain clinical confidence in their MHT treatments.
Precision Analytical, Inc. published its first peer-reviewed journal in BMC Chemistry in 2019. Since then, our rigorous pursuit for the truth has led us to author multiple peer-reviewed research studies exploring the effectiveness and accuracy of dried urine testing to measure comprehensive hormones. We invite you to explore our other research, and discover how the DUTCH Test® can be a valuable tool to solve complex patient problems.
SIGN UP FOR OUR MONTHLY NEWSLETTER TO STAY CONNECTED
WITH OUR COMMUNITY OF DOCTORS, RESEARCHERS, AND SCIENTISTS
