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Monitoring Transdermal Estradiol Gel Therapy
With a Validated Dried Urine Assay
Mark Newman, MS1; Doreen Saltiel, MD, JD1,2; Bryan P. Mayfield, PharmD1,3; Frank Stanczyk, PhD4
1Precision Analytical, McMinnville, OR; 2Peak Health and Wellness, Asheville, NC; 3Texas Tech University Health Sciences Center Jerry H. Hodge School of Pharmacy, Lubbock, TX; 4University of California Keck School of Medicine, Los Angeles, CA
Research
Transdermal (TD) estradiol (E2) gel is a commonly used menopausal hormone therapy (MHT). Serum is often used to measure E2 levels, but the results only represent a moment in time rather than a complete picture of hormone health. The aim of this study was to evaluate a dried urine sampling method to determine if it may be a viable option for monitoring MHT administered via TD gel. We set out to determine if urine could provide an alternative to serum E2 levels as it is non-invasive and easier to collect.
Pharmacokinetics of Transdermal Estradiol Gel in Serum
Results
This large population-based study using real-world data demonstrated that a dried urine assay (i.e. the DUTCH Test®) is a viable method of monitoring changes in women’s urinary E2 profiles in response to MHT with differing doses of TD E2 gel. These results suggest that the validated dried urine assay used in this study can be used as an attractive alternative to serum for exploring not only the changes in the urinary E2 profile but also the efficacy and effectiveness of TD E2 gels for MHT.
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References
1. Newman M, Pratt SM, Curran DA, Stanczyk FZ. Evaluating urinary estrogen and progesterone metabolites using dried filter paper samples and gas chromatography with tandem mass spectrometry (GC–MS/MS). BMC Chemistry. 2019;13(1):1-12. doi:10.1186/s13065-019-0539-1
More DUTCH Research
With a validated test, providers gain clinical confidence in their MHT treatments.
Precision Analytical, Inc. published its first peer-reviewed journal in BMC Chemistry in 2019. Since then, our rigorous pursuit for the truth has led us to author multiple peer-reviewed research studies exploring the effectiveness and accuracy of dried urine testing to measure comprehensive hormones. We invite you to explore our other research, and discover how the DUTCH Test® can be a valuable tool to solve complex patient problems.
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